This project began with an assessment of the HSP community’s needs. All of the available published scholarly articles available on HSPs with a mention of white matter abnormalities were reviewed. The MRIs available in these articles were reviewed by 3 independent raters blind to the diagnosis of each MRI, and inter-rater consensus was reached.

The MRI findings were compiled into a database, along with additional information, and sorted by each gene. This database was then used to train an algorithm to detect and best-match white matter abnormalities that are seen on MRI. This algorithm was used to develop the tool found here.